Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3667110..3667767 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag OI907_RS18015 Protein ID WP_033146338.1
Coordinates 3667468..3667767 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag OI907_RS18010 Protein ID WP_033146339.1
Coordinates 3667110..3667457 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS17980 (OI907_17960) 3662726..3663613 + 888 WP_033146345.1 LysR family transcriptional regulator -
OI907_RS17985 (OI907_17965) 3663633..3664814 + 1182 WP_033146344.1 PLP-dependent aminotransferase family protein -
OI907_RS17990 (OI907_17970) 3664899..3665417 + 519 WP_033146343.1 hypothetical protein -
OI907_RS17995 (OI907_17975) 3665420..3665839 - 420 WP_033146342.1 nuclear transport factor 2 family protein -
OI907_RS18000 (OI907_17980) 3665937..3666668 + 732 WP_033146341.1 helix-turn-helix transcriptional regulator -
OI907_RS18005 (OI907_17985) 3666640..3667065 - 426 WP_033146340.1 nucleoside triphosphatase NudI -
OI907_RS18010 (OI907_17990) 3667110..3667457 - 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
OI907_RS18015 (OI907_17995) 3667468..3667767 - 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI907_RS18020 (OI907_18000) 3668021..3669190 - 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
OI907_RS18025 (OI907_18005) 3669201..3671399 - 2199 WP_033146337.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T261987 WP_033146338.1 NZ_CP109692:c3667767-3667468 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT261987 WP_033146339.1 NZ_CP109692:c3667457-3667110 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References