Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2512183..2512829 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OI907_RS12445 Protein ID WP_033147058.1
Coordinates 2512183..2512533 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OI907_RS12450 Protein ID WP_023309874.1
Coordinates 2512530..2512829 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS12430 (OI907_12415) 2507634..2509952 - 2319 WP_033147056.1 alpha-xylosidase -
OI907_RS12435 (OI907_12420) 2509965..2511356 - 1392 WP_033147057.1 glycoside-pentoside-hexuronide family transporter -
OI907_RS12445 (OI907_12430) 2512183..2512533 + 351 WP_033147058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI907_RS12450 (OI907_12435) 2512530..2512829 + 300 WP_023309874.1 XRE family transcriptional regulator Antitoxin
OI907_RS12455 (OI907_12440) 2512858..2513295 - 438 WP_033147059.1 acetyltransferase -
OI907_RS12460 (OI907_12445) 2513652..2514650 - 999 WP_033147060.1 class I SAM-dependent methyltransferase -
OI907_RS12465 (OI907_12450) 2514736..2515674 - 939 WP_047059676.1 helix-turn-helix domain-containing protein -
OI907_RS12470 (OI907_12455) 2515864..2516343 - 480 WP_033147061.1 hypothetical protein -
OI907_RS12475 (OI907_12460) 2516345..2517106 - 762 WP_033147062.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13561.65 Da        Isoelectric Point: 8.0081

>T261984 WP_033147058.1 NZ_CP109692:2512183-2512533 [Enterobacter asburiae]
MWTVLFGKVFEQWLLEQEEGLQDKVLADLLNLQKYGPRLPRPYADTVKGSWYNHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKAFYEKMIRIADTEFSFHLTSLEATK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11165.99 Da        Isoelectric Point: 7.2052

>AT261984 WP_023309874.1 NZ_CP109692:2512530-2512829 [Enterobacter asburiae]
VKTLNEVIASRSPESQQRIKEMADEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAMG
GKLHIDIELPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References