261964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 2431089..2431591 Replicon chromosome
Accession NZ_CP109619
Organism Treponema denticola strain KCOM 3500

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E2EC53
Locus tag OE909_RS11365 Protein ID WP_002672679.1
Coordinates 2431331..2431591 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E2ECR9
Locus tag OE909_RS11360 Protein ID WP_002672677.1
Coordinates 2431089..2431331 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE909_RS11335 (OE909_11335) 2427260..2428540 - 1281 WP_264306792.1 amino acid permease -
OE909_RS11340 (OE909_11340) 2428593..2429318 - 726 WP_264306793.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
OE909_RS11345 (OE909_11345) 2429372..2430346 - 975 WP_264306794.1 hypothetical protein -
OE909_RS11350 (OE909_11350) 2430529..2430762 + 234 WP_002692434.1 hypothetical protein -
OE909_RS11355 (OE909_11355) 2430860..2431027 + 168 WP_264307679.1 type II toxin-antitoxin system RelE/ParE family toxin -
OE909_RS11360 (OE909_11360) 2431089..2431331 + 243 WP_002672677.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OE909_RS11365 (OE909_11365) 2431331..2431591 + 261 WP_002672679.1 Txe/YoeB family addiction module toxin Toxin
OE909_RS11370 (OE909_11370) 2431640..2432050 + 411 WP_253717413.1 hypothetical protein -
OE909_RS11375 (OE909_11375) 2432118..2432399 - 282 WP_253730987.1 helix-turn-helix transcriptional regulator -
OE909_RS11380 (OE909_11380) 2432935..2433336 - 402 WP_264306795.1 hypothetical protein -
OE909_RS11385 (OE909_11385) 2433433..2435631 - 2199 WP_264306796.1 lanthionine synthetase LanC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(18-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10379.10 Da        Isoelectric Point: 10.1554

>T261964 WP_002672679.1 NZ_CP109619:2431331-2431591 [Treponema denticola]
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE

Download         Length: 261 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9175.34 Da        Isoelectric Point: 4.1317

>AT261964 WP_002672677.1 NZ_CP109619:2431089-2431331 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2EC53

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2ECR9

References