261962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1811881..1812507 Replicon chromosome
Accession NZ_CP109619
Organism Treponema denticola strain KCOM 3500

Toxin (Protein)


Gene name higB Uniprot ID Q73NN6
Locus tag OE909_RS08330 Protein ID WP_002677634.1
Coordinates 1811881..1812189 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OE909_RS08335 Protein ID WP_002689588.1
Coordinates 1812199..1812507 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE909_RS08305 (OE909_08305) 1807836..1808174 + 339 WP_002670686.1 anti-sigma factor antagonist -
OE909_RS08310 (OE909_08310) 1808191..1808733 + 543 WP_002670683.1 ATP-binding protein -
OE909_RS08315 (OE909_08315) 1808748..1809569 - 822 WP_264306470.1 hypothetical protein -
OE909_RS08320 (OE909_08320) 1809550..1810170 - 621 WP_002670678.1 hypothetical protein -
OE909_RS08325 (OE909_08325) 1810286..1811665 + 1380 WP_264306471.1 tyrosine phenol-lyase -
OE909_RS08330 (OE909_08330) 1811881..1812189 + 309 WP_002677634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OE909_RS08335 (OE909_08335) 1812199..1812507 + 309 WP_002689588.1 NadS family protein Antitoxin
OE909_RS08340 (OE909_08340) 1812640..1813311 + 672 WP_002670670.1 TetR/AcrR family transcriptional regulator -
OE909_RS08345 (OE909_08345) 1813400..1813816 + 417 WP_245522456.1 SRPBCC family protein -
OE909_RS08350 (OE909_08350) 1813947..1814576 - 630 WP_002670667.1 adenylate kinase -
OE909_RS08355 (OE909_08355) 1814634..1815863 - 1230 WP_002670666.1 cation:dicarboxylase symporter family transporter -
OE909_RS08360 (OE909_08360) 1815902..1817221 - 1320 WP_264306472.1 leucine-rich repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.96 Da        Isoelectric Point: 10.6864

>T261962 WP_002677634.1 NZ_CP109619:1811881-1812189 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Download         Length: 309 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11563.46 Da        Isoelectric Point: 9.6884

>AT261962 WP_002689588.1 NZ_CP109619:1812199-1812507 [Treponema denticola]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPSRIFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73NN6

Antitoxin

Source ID Structure

References