Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-RNAII/-
Location 2608155..2608413 Replicon chromosome
Accession NZ_CP109611
Organism Enterococcus faecalis strain AFL-109F

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag OGM83_RS12695 Protein ID WP_002392696.1
Coordinates 2608270..2608413 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RNAII
Locus tag -
Coordinates 2608155..2608337 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM83_RS12680 (2603716) 2603716..2604429 - 714 WP_002367455.1 trehalose operon repressor -
OGM83_RS12685 (2604691) 2604691..2607435 + 2745 WP_283658616.1 glycosyl hydrolase family 65 protein -
OGM83_RS12690 (2607450) 2607450..2608100 + 651 WP_033597602.1 beta-phosphoglucomutase -
- (2608169) 2608169..2608296 + 128 NuclAT_13 - -
- (2608155) 2608155..2608337 + 183 NuclAT_10 - Antitoxin
OGM83_RS12695 (2608270) 2608270..2608413 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
OGM83_RS12700 (2608644) 2608644..2609615 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
OGM83_RS12705 (2609790) 2609790..2610227 - 438 WP_271232303.1 peptide-methionine (R)-S-oxide reductase MsrB -
OGM83_RS12710 (2610360) 2610360..2610914 - 555 WP_002354869.1 Maf family protein -
OGM83_RS12715 (2610939) 2610939..2613071 - 2133 WP_057086606.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T261933 WP_002392696.1 NZ_CP109611:c2608413-2608270 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 183 bp

>AT261933 NZ_CP109611:2608155-2608337 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGCTGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACTTTTTGAAT
TATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References