Detailed information of TA system TA261926

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2545314..2545574
• Replicon: chromosome
• Accession: NZ_CP109611
• Organism: Enterococcus faecalis strain AFL-109F

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OGM83_RS12405
• Protein ID: WP_021164442.1
• Coordinates: 2545473..2545574 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2545314..2545519 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OGM83_RS12380 (2540968)	2540968..2541921	-	954	WP_271232295.1	siderophore ABC transporter substrate-binding protein	-
OGM83_RS12385 (2541960)	2541960..2542715	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OGM83_RS12390 (2542712)	2542712..2543677	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
OGM83_RS12395 (2543674)	2543674..2544621	-	948	WP_002368428.1	iron chelate uptake ABC transporter family permease subunit	-
OGM83_RS12400 (2544806)	2544806..2545258	+	453	WP_002359057.1	YueI family protein	-
- (2545314)	2545314..2545519	+	206	NuclAT_7	-	Antitoxin
- (2545351)	2545351..2545536	+	186	NuclAT_5	-	-
OGM83_RS12405 (2545473)	2545473..2545574	-	102	WP_021164442.1	putative holin-like toxin	Toxin
- (2545749)	2545749..2545958	+	210	NuclAT_6	-	-
- (2545783)	2545783..2545962	+	180	NuclAT_4	-	-
OGM83_RS12410 (2545907)	2545907..2546008	-	102	WP_075551663.1	putative holin-like toxin	-
OGM83_RS12415 (2546197)	2546197..2548467	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OGM83_RS12420 (2548638)	2548638..2549138	+	501	WP_002354954.1	cysteine hydrolase family protein	-
OGM83_RS12425 (2549484)	2549484..2550380	+	897	WP_002365354.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T261926 WP_021164442.1 NZ_CP109611:c2545574-2545473 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 206 bp

>AT261926 NZ_CP109611:2545314-2545519 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAACG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCATTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin