Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3777611..3778208 Replicon chromosome
Accession NZ_CP109604
Organism Klebsiella pneumoniae strain KP2022

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag KP2022_RS18515 Protein ID WP_004142563.1
Coordinates 3777891..3778208 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag KP2022_RS18510 Protein ID WP_004142561.1
Coordinates 3777611..3777898 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP2022_RS18480 (3773691) 3773691..3773939 + 249 WP_002893037.1 DUF1158 domain-containing protein -
KP2022_RS18485 (3773957) 3773957..3774298 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
KP2022_RS18490 (3774329) 3774329..3775444 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
KP2022_RS18495 (3775624) 3775624..3776208 + 585 WP_002893026.1 TetR/AcrR family transcriptional regulator -
KP2022_RS18500 (3776205) 3776205..3776573 + 369 WP_002893024.1 MmcQ/YjbR family DNA-binding protein -
KP2022_RS18505 (3776693) 3776693..3777346 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
KP2022_RS18510 (3777611) 3777611..3777898 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
KP2022_RS18515 (3777891) 3777891..3778208 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP2022_RS18520 (3778393) 3778393..3779436 - 1044 WP_087761125.1 DUF2157 domain-containing protein -
KP2022_RS18525 (3780102) 3780102..3780968 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
KP2022_RS18530 (3781077) 3781077..3782504 + 1428 WP_129073911.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T261892 WP_004142563.1 NZ_CP109604:c3778208-3777891 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT261892 WP_004142561.1 NZ_CP109604:c3777898-3777611 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References