Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350297..350943 Replicon chromosome
Accession NZ_CP109604
Organism Klebsiella pneumoniae strain KP2022

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag KP2022_RS01615 Protein ID WP_004174016.1
Coordinates 350297..350644 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag KP2022_RS01620 Protein ID WP_004174017.1
Coordinates 350644..350943 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP2022_RS01605 (346223) 346223..347656 + 1434 WP_002920564.1 glycogen synthase GlgA -
KP2022_RS01610 (347674) 347674..350121 + 2448 WP_002920561.1 glycogen phosphorylase -
KP2022_RS01615 (350297) 350297..350644 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP2022_RS01620 (350644) 350644..350943 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
KP2022_RS01625 (351006) 351006..352514 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
KP2022_RS01630 (352719) 352719..353048 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KP2022_RS01635 (353099) 353099..353929 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KP2022_RS01640 (353979) 353979..354737 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T261885 WP_004174016.1 NZ_CP109604:350297-350644 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT261885 WP_004174017.1 NZ_CP109604:350644-350943 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References