Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3716897..3717438 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag OGV15_RS18175 Protein ID WP_000615983.1
Coordinates 3717160..3717438 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag OGV15_RS18170 Protein ID WP_000729703.1
Coordinates 3716897..3717157 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS18150 (3712572) 3712572..3713357 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
OGV15_RS18155 (3713329) 3713329..3715041 + 1713 Protein_3551 flagellar biosynthesis protein FlhA -
OGV15_RS18160 (3715265) 3715265..3715762 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
OGV15_RS18165 (3715938) 3715938..3716687 - 750 WP_000056849.1 C40 family peptidase -
OGV15_RS18170 (3716897) 3716897..3717157 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OGV15_RS18175 (3717160) 3717160..3717438 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OGV15_RS18180 (3717594) 3717594..3718334 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OGV15_RS18185 (3718305) 3718305..3719072 - 768 WP_000333380.1 class II glutamine amidotransferase -
OGV15_RS18190 (3719278) 3719278..3719856 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T261863 WP_000615983.1 NZ_CP109601:3717160-3717438 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT261863 WP_000729703.1 NZ_CP109601:3716897-3717157 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References