Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 779727..780420 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag OGV15_RS03800 Protein ID WP_000415584.1
Coordinates 779727..780023 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OGV15_RS03805 Protein ID WP_000650107.1
Coordinates 780025..780420 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS03765 (774814) 774814..775128 - 315 WP_000958598.1 putative quinol monooxygenase -
OGV15_RS03770 (775159) 775159..775740 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OGV15_RS03775 (776059) 776059..776391 + 333 WP_000917684.1 DUF2645 family protein -
OGV15_RS03780 (776437) 776437..777786 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
OGV15_RS03785 (777783) 777783..778442 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
OGV15_RS03790 (778594) 778594..778986 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OGV15_RS03795 (779039) 779039..779522 + 484 Protein_744 GyrI-like domain-containing protein -
OGV15_RS03800 (779727) 779727..780023 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
OGV15_RS03805 (780025) 780025..780420 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OGV15_RS03810 (780553) 780553..782160 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OGV15_RS03815 (782298) 782298..784556 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T261849 WP_000415584.1 NZ_CP109601:779727-780023 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT261849 WP_000650107.1 NZ_CP109601:780025-780420 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References