261817

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 659137..659936 Replicon chromosome
Accession NZ_CP107720
Organism Escherichia coli strain 2021CK-01361

Toxin (Protein)


Gene name yhaV Uniprot ID D7XZ20
Locus tag N4T39_RS03220 Protein ID WP_000347264.1
Coordinates 659137..659601 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N4T39_RS03225 Protein ID WP_001307405.1
Coordinates 659601..659936 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T39_RS03190 (654138) 654138..654572 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N4T39_RS03195 (654590) 654590..655468 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
N4T39_RS03200 (655458) 655458..656237 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N4T39_RS03205 (656248) 656248..656721 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N4T39_RS03210 (656744) 656744..658024 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
N4T39_RS03215 (658273) 658273..659082 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N4T39_RS03220 (659137) 659137..659601 - 465 WP_000347264.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N4T39_RS03225 (659601) 659601..659936 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N4T39_RS03230 (660085) 660085..661656 - 1572 WP_001273753.1 galactarate dehydratase -
N4T39_RS03235 (662031) 662031..663365 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N4T39_RS03240 (663381) 663381..664151 + 771 WP_001058207.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17894.29 Da        Isoelectric Point: 9.4945

>T261817 WP_000347264.1 NZ_CP107720:c659601-659137 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFDAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT261817 WP_001307405.1 NZ_CP107720:c659936-659601 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241QML2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References