Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4591..5242 Replicon plasmid unnamed1
Accession NZ_CP107611
Organism Acinetobacter baumannii strain 1326924-3

Toxin (Protein)


Gene name higB Uniprot ID V2UF49
Locus tag OIO64_RS19120 Protein ID WP_000269909.1
Coordinates 4886..5242 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIO64_RS19115 Protein ID WP_001140621.1
Coordinates 4591..4893 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO64_RS19090 (OIO64_19095) 170..457 + 288 WP_000438827.1 BrnT family toxin -
OIO64_RS19095 (OIO64_19100) 444..758 + 315 WP_001983304.1 BrnA antitoxin family protein -
OIO64_RS19100 (OIO64_19105) 886..3297 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO64_RS19105 (OIO64_19110) 3602..4063 + 462 WP_000761346.1 DIP1984 family protein -
OIO64_RS19110 (OIO64_19115) 4389..4598 - 210 WP_000069474.1 hypothetical protein -
OIO64_RS19115 (OIO64_19120) 4591..4893 - 303 WP_001140621.1 XRE family transcriptional regulator Antitoxin
OIO64_RS19120 (OIO64_19125) 4886..5242 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIO64_RS19125 (OIO64_19130) 6048..6881 - 834 WP_000439570.1 S-formylglutathione hydrolase -
OIO64_RS19130 (OIO64_19135) 7355..7753 - 399 WP_000235176.1 VOC family protein -
OIO64_RS19135 (OIO64_19140) 7806..8915 - 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
OIO64_RS19140 (OIO64_19145) 8937..9212 - 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
OIO64_RS19145 (OIO64_19150) 9798..9944 + 147 WP_001983317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13515.49 Da        Isoelectric Point: 6.4631

>T261803 WP_000269909.1 NZ_CP107611:c5242-4886 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT261803 WP_001140621.1 NZ_CP107611:c4893-4591 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2UF49

Antitoxin

Source ID Structure

References