Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 14386..15037 Replicon plasmid unnamed1
Accession NZ_CP107598
Organism Acinetobacter baumannii strain 1326581-2

Toxin (Protein)


Gene name higB Uniprot ID V2UF49
Locus tag OIO78_RS19120 Protein ID WP_000269909.1
Coordinates 14386..14742 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIO78_RS19125 Protein ID WP_001140621.1
Coordinates 14735..15037 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO78_RS19095 (OIO78_19100) 11949..12161 + 213 WP_000687427.1 hypothetical protein -
OIO78_RS19100 (OIO78_19105) 12443..12619 + 177 WP_000246872.1 hypothetical protein -
OIO78_RS19105 (OIO78_19110) 12655..13149 + 495 WP_000999995.1 hypothetical protein -
OIO78_RS19110 (OIO78_19115) 13164..13448 - 285 WP_001071102.1 hypothetical protein -
OIO78_RS19115 (OIO78_19120) 13542..13844 + 303 WP_000702763.1 hypothetical protein -
OIO78_RS19120 (OIO78_19125) 14386..14742 + 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIO78_RS19125 (OIO78_19130) 14735..15037 + 303 WP_001140621.1 XRE family transcriptional regulator Antitoxin
OIO78_RS19130 (OIO78_19135) 15030..15239 + 210 WP_000069474.1 hypothetical protein -
OIO78_RS19135 (OIO78_19140) 15565..16026 - 462 WP_000761346.1 DIP1984 family protein -
OIO78_RS19140 (OIO78_19145) 16331..18742 - 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO78_RS19145 (OIO78_19150) 18870..19184 - 315 WP_001983304.1 BrnA antitoxin family protein -
OIO78_RS19150 (OIO78_19155) 19171..19458 - 288 WP_000438827.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13515.49 Da        Isoelectric Point: 6.4631

>T261786 WP_000269909.1 NZ_CP107598:14386-14742 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT261786 WP_001140621.1 NZ_CP107598:14735-15037 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2UF49

Antitoxin

Source ID Structure

References