261770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4694..5345 Replicon plasmid unnamed1
Accession NZ_CP107586
Organism Acinetobacter baumannii strain 1326527-1

Toxin (Protein)


Gene name higB Uniprot ID V2UF49
Locus tag OIO72_RS19135 Protein ID WP_000269909.1
Coordinates 4989..5345 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIO72_RS19130 Protein ID WP_001140621.1
Coordinates 4694..4996 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO72_RS19105 (OIO72_19110) 273..560 + 288 WP_000438827.1 BrnT family toxin -
OIO72_RS19110 (OIO72_19115) 547..861 + 315 WP_001983304.1 BrnA antitoxin family protein -
OIO72_RS19115 (OIO72_19120) 989..3400 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO72_RS19120 (OIO72_19125) 3705..4166 + 462 WP_000761346.1 DIP1984 family protein -
OIO72_RS19125 (OIO72_19130) 4492..4701 - 210 WP_000069474.1 hypothetical protein -
OIO72_RS19130 (OIO72_19135) 4694..4996 - 303 WP_001140621.1 XRE family transcriptional regulator Antitoxin
OIO72_RS19135 (OIO72_19140) 4989..5345 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIO72_RS19140 (OIO72_19145) 6151..6984 - 834 WP_000439570.1 S-formylglutathione hydrolase -
OIO72_RS19145 (OIO72_19150) 7458..7856 - 399 WP_000235176.1 VOC family protein -
OIO72_RS19150 (OIO72_19155) 7909..9018 - 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
OIO72_RS19155 (OIO72_19160) 9040..9315 - 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
OIO72_RS19160 (OIO72_19165) 9901..10047 + 147 WP_001983317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13515.49 Da        Isoelectric Point: 6.4631

>T261770 WP_000269909.1 NZ_CP107586:c5345-4989 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT261770 WP_001140621.1 NZ_CP107586:c4996-4694 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2UF49

Antitoxin

Source ID Structure

References