Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 555..1206 Replicon plasmid unnamed1
Accession NZ_CP107582
Organism Acinetobacter baumannii strain 1326525-2

Toxin (Protein)


Gene name higB Uniprot ID V2UF49
Locus tag OIO86_RS19075 Protein ID WP_000269909.1
Coordinates 555..911 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIO86_RS19080 Protein ID WP_001140621.1
Coordinates 904..1206 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO86_RS19075 (OIO86_19080) 555..911 + 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIO86_RS19080 (OIO86_19085) 904..1206 + 303 WP_001140621.1 XRE family transcriptional regulator Antitoxin
OIO86_RS19085 (OIO86_19090) 1199..1408 + 210 WP_000069474.1 hypothetical protein -
OIO86_RS19090 (OIO86_19095) 1734..2195 - 462 WP_000761346.1 DIP1984 family protein -
OIO86_RS19095 (OIO86_19100) 2500..4911 - 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO86_RS19100 (OIO86_19105) 5039..5353 - 315 WP_001983304.1 BrnA antitoxin family protein -
OIO86_RS19105 (OIO86_19110) 5340..5627 - 288 WP_000438827.1 BrnT family toxin -
OIO86_RS19110 (OIO86_19115) 5874..6176 - 303 WP_000702763.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13515.49 Da        Isoelectric Point: 6.4631

>T261764 WP_000269909.1 NZ_CP107582:555-911 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT261764 WP_001140621.1 NZ_CP107582:904-1206 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2UF49

Antitoxin

Source ID Structure

References