Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 573448..574102 Replicon plasmid pJL.02bL
Accession NZ_CP107574
Organism Pantoea dispersa strain JL.02bL

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OF384_RS22120 Protein ID WP_058770321.1
Coordinates 573448..573819 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NDM6
Locus tag OF384_RS22125 Protein ID WP_021508926.1
Coordinates 573803..574102 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF384_RS22100 (OF384_22100) 568724..570103 + 1380 WP_264251845.1 heavy metal sensor histidine kinase -
OF384_RS22105 (OF384_22105) 570141..570794 - 654 WP_021508932.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
OF384_RS22110 (OF384_22110) 570899..571900 - 1002 WP_264251846.1 zinc-binding alcohol dehydrogenase family protein -
OF384_RS22115 (OF384_22115) 572037..572954 + 918 WP_058759023.1 LysR family transcriptional regulator -
OF384_RS22120 (OF384_22120) 573448..573819 + 372 WP_058770321.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF384_RS22125 (OF384_22125) 573803..574102 + 300 WP_021508926.1 XRE family transcriptional regulator Antitoxin
OF384_RS22130 (OF384_22130) 574180..574647 - 468 WP_058759022.1 hypothetical protein -
OF384_RS22135 (OF384_22135) 574833..575762 - 930 WP_264251847.1 ABC transporter substrate-binding protein -
OF384_RS22140 (OF384_22140) 575772..576506 - 735 WP_264251848.1 ABC transporter permease -
OF384_RS22145 (OF384_22145) 576490..577206 - 717 WP_215788040.1 ABC transporter ATP-binding protein -
OF384_RS22150 (OF384_22150) 577203..578171 - 969 WP_264251849.1 HesA/MoeB/ThiF family protein -
OF384_RS22155 (OF384_22155) 578182..578940 - 759 WP_058776079.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..696693 696693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-88)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14357.53 Da        Isoelectric Point: 10.3096

>T261754 WP_058770321.1 NZ_CP107574:573448-573819 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHHHLNAIGETHNENLG

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11265.00 Da        Isoelectric Point: 6.7255

>AT261754 WP_021508926.1 NZ_CP107574:573803-574102 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVDERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NDM6

References