Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 3224931..3225655 | Replicon | chromosome |
Accession | NZ_CP107573 | ||
Organism | Pantoea dispersa strain JL.02bL |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | OF384_RS15285 | Protein ID | WP_215480918.1 |
Coordinates | 3224931..3225242 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | OF384_RS15290 | Protein ID | WP_021313564.1 |
Coordinates | 3225239..3225655 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OF384_RS15270 (OF384_15270) | 3220256..3222706 | + | 2451 | WP_058776018.1 | acyl-CoA dehydrogenase FadE | - |
OF384_RS15275 (OF384_15275) | 3222891..3224051 | + | 1161 | WP_264249307.1 | pyridoxal phosphate-dependent aminotransferase | - |
OF384_RS15280 (OF384_15280) | 3224039..3224809 | + | 771 | WP_104189157.1 | amidohydrolase | - |
OF384_RS15285 (OF384_15285) | 3224931..3225242 | + | 312 | WP_215480918.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
OF384_RS15290 (OF384_15290) | 3225239..3225655 | + | 417 | WP_021313564.1 | transcriptional regulator | Antitoxin |
OF384_RS15295 (OF384_15295) | 3225697..3227895 | - | 2199 | WP_031279672.1 | catalase/peroxidase HPI | - |
OF384_RS15300 (OF384_15300) | 3228190..3228525 | - | 336 | WP_021507290.1 | hydroxyisourate hydrolase | - |
OF384_RS15305 (OF384_15305) | 3228522..3229016 | - | 495 | WP_058769329.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
OF384_RS15310 (OF384_15310) | 3229029..3230288 | - | 1260 | WP_132466329.1 | allantoate amidohydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12183.06 Da Isoelectric Point: 10.3546
>T261748 WP_215480918.1 NZ_CP107573:3224931-3225242 [Pantoea dispersa]
MHIISRKVFNEATQRFPNDAAALDATYRLLSGHDFADPQALKAWFPSLDRMKYRAKWWVINVGGNNLRLMFFADFVAKRV
FVKHIVTHAEYDKLVKHYRENKE
MHIISRKVFNEATQRFPNDAAALDATYRLLSGHDFADPQALKAWFPSLDRMKYRAKWWVINVGGNNLRLMFFADFVAKRV
FVKHIVTHAEYDKLVKHYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 15331.57 Da Isoelectric Point: 7.4011
>AT261748 WP_021313564.1 NZ_CP107573:3225239-3225655 [Pantoea dispersa]
MISEAIQASNNLIKAVPLLGGSQSRADYEQALELVEYLVEHQPGHPLIEMLAVKVAKYEETAAEFAAFNARTQALPGGVA
LLRVLMDQHGLNQSSFVAEIGQRSYVNRILKGERRLTDKHKAALARRFNLPFEAFREA
MISEAIQASNNLIKAVPLLGGSQSRADYEQALELVEYLVEHQPGHPLIEMLAVKVAKYEETAAEFAAFNARTQALPGGVA
LLRVLMDQHGLNQSSFVAEIGQRSYVNRILKGERRLTDKHKAALARRFNLPFEAFREA
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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