Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 178300..178980 Replicon chromosome
Accession NZ_CP107573
Organism Pantoea dispersa strain JL.02bL

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OF384_RS00815 Protein ID WP_264250233.1
Coordinates 178300..178599 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NHX0
Locus tag OF384_RS00820 Protein ID WP_058775157.1
Coordinates 178648..178980 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF384_RS00800 (OF384_00800) 174704..175198 + 495 WP_021507883.1 GNAT family N-acetyltransferase -
OF384_RS00805 (OF384_00805) 175496..176410 - 915 WP_021507882.1 sugar ABC transporter substrate-binding protein -
OF384_RS00810 (OF384_00810) 176846..178240 + 1395 WP_058775155.1 MFS transporter -
OF384_RS00815 (OF384_00815) 178300..178599 + 300 WP_264250233.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF384_RS00820 (OF384_00820) 178648..178980 + 333 WP_058775157.1 HigA family addiction module antitoxin Antitoxin
OF384_RS00825 (OF384_00825) 179072..180235 + 1164 WP_021507880.1 HD-GYP domain-containing protein -
OF384_RS00830 (OF384_00830) 180344..180433 + 90 WP_021507879.1 K(+)-transporting ATPase subunit F -
OF384_RS00835 (OF384_00835) 180433..182112 + 1680 WP_264250237.1 potassium-transporting ATPase subunit KdpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11530.28 Da        Isoelectric Point: 10.6015

>T261744 WP_264250233.1 NZ_CP107573:178300-178599 [Pantoea dispersa]
MGSIRAFRQAWLAQFYTHGKPHAQIPRAIESALARKLDIIHAATSHQDLRSPPGNRFEALKPPLLGYYSIRVNAQYRLIF
QWAKGEAWDLYLDPHRYKK

Download         Length: 300 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12751.58 Da        Isoelectric Point: 7.2039

>AT261744 WP_058775157.1 NZ_CP107573:178648-178980 [Pantoea dispersa]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLSTEMAYRLARVFATSIEFWLNLQRHLDQW
EVENDARTQEELSRVMTLSAFLAQRGTQVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NHX0

References