Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1892662..1893401 Replicon chromosome
Accession NC_017027
Organism Pasteurella multocida subsp. multocida str. HN06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PMCN06_RS08820 Protein ID WP_015690952.1
Coordinates 1892662..1892988 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PMCN06_RS08825 Protein ID WP_015690953.1
Coordinates 1893075..1893401 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMCN06_RS08795 1887967..1888653 + 687 WP_015690949.1 hypothetical protein -
PMCN06_RS08800 1888719..1890248 - 1530 WP_015690950.1 YifB family Mg chelatase-like AAA ATPase -
PMCN06_RS08805 1890356..1890973 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
PMCN06_RS08810 1891084..1891953 + 870 WP_015690951.1 VirK/YbjX family protein -
PMCN06_RS08815 1892028..1892504 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PMCN06_RS08820 1892662..1892988 + 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMCN06_RS08825 1893075..1893401 + 327 WP_015690953.1 HigA family addiction module antidote protein Antitoxin
PMCN06_RS08830 1893455..1894975 - 1521 WP_015690954.1 DUF560 domain-containing protein -
PMCN06_RS08835 1895034..1895636 - 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
PMCN06_RS08840 1895723..1896673 - 951 WP_015690956.1 hypothetical protein -
PMCN06_RS08845 1896912..1897946 - 1035 WP_015690957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T26172 WP_015690952.1 NC_017027:1892662-1892988 [Pasteurella multocida subsp. multocida str. HN06]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T26172 NC_017027:1892662-1892988 [Pasteurella multocida subsp. multocida str. HN06]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAATG
ATTTGCGAAGTCCACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT26172 WP_015690953.1 NC_017027:1893075-1893401 [Pasteurella multocida subsp. multocida str. HN06]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp

>AT26172 NC_017027:1893075-1893401 [Pasteurella multocida subsp. multocida str. HN06]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCAAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTTGTCTATTGATCAGCATAACCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References