Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2113304..2113817 Replicon chromosome
Accession NZ_CP107524
Organism Streptococcus agalactiae strain SA5087

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag OFY20_RS10775 Protein ID WP_000481712.1
Coordinates 2113304..2113558 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag OFY20_RS10780 Protein ID WP_000387490.1
Coordinates 2113551..2113817 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY20_RS10755 (OFY20_10755) 2109076..2111577 - 2502 WP_000239405.1 ATP-binding protein -
OFY20_RS10760 (OFY20_10760) 2111598..2112008 - 411 WP_000390748.1 conjugal transfer protein -
OFY20_RS10765 (OFY20_10765) 2112012..2112278 - 267 WP_001055036.1 hypothetical protein -
OFY20_RS10770 (OFY20_10770) 2112298..2113251 - 954 WP_000565542.1 conjugal transfer protein -
OFY20_RS10775 (OFY20_10775) 2113304..2113558 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
OFY20_RS10780 (OFY20_10780) 2113551..2113817 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OFY20_RS10785 (OFY20_10785) 2113962..2114435 - 474 WP_000560386.1 hypothetical protein -
OFY20_RS10790 (OFY20_10790) 2114443..2114925 - 483 WP_000383282.1 antirestriction protein ArdA -
OFY20_RS10795 (OFY20_10795) 2114977..2115250 - 274 Protein_2056 hypothetical protein -
OFY20_RS10800 (OFY20_10800) 2115382..2115735 - 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
OFY20_RS10805 (OFY20_10805) 2115728..2115943 - 216 WP_001897988.1 helix-turn-helix transcriptional regulator -
OFY20_RS10810 (OFY20_10810) 2115927..2116304 - 378 WP_000287184.1 hypothetical protein -
OFY20_RS10815 (OFY20_10815) 2116320..2117552 - 1233 WP_000338840.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2098783..2139021 40238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T261718 WP_000481712.1 NZ_CP107524:c2113558-2113304 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT261718 WP_000387490.1 NZ_CP107524:c2113817-2113551 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References