Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3055041..3055627 Replicon chromosome
Accession NZ_CP107513
Organism Klebsiella pneumoniae strain CRKP_2

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag OH512_RS14915 Protein ID WP_002920800.1
Coordinates 3055259..3055627 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag OH512_RS14910 Protein ID WP_002920802.1
Coordinates 3055041..3055262 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH512_RS14890 3051198..3052124 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
OH512_RS14895 3052121..3053398 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
OH512_RS14900 3053395..3054162 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
OH512_RS14905 3054164..3054877 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
OH512_RS14910 3055041..3055262 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OH512_RS14915 3055259..3055627 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OH512_RS14920 3055900..3057216 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
OH512_RS14925 3057323..3058210 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
OH512_RS14930 3058207..3059052 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
OH512_RS14935 3059054..3060124 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3052121..3060861 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T261668 WP_002920800.1 NZ_CP107513:3055259-3055627 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT261668 WP_002920802.1 NZ_CP107513:3055041-3055262 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References