Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 36502..36928 Replicon plasmid unnamed2
Accession NZ_CP107480
Organism Klebsiella pneumoniae strain CRKP_9

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag OH537_RS28295 Protein ID WP_001372321.1
Coordinates 36502..36627 (-) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 36704..36928 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH537_RS28260 (31557) 31557..31784 - 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -
OH537_RS28265 (31878) 31878..32564 - 687 WP_015059009.1 PAS domain-containing protein -
OH537_RS28270 (32755) 32755..33138 - 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
OH537_RS28275 (33415) 33415..34062 + 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
OH537_RS28280 (34359) 34359..35180 - 822 WP_001234445.1 DUF932 domain-containing protein -
OH537_RS28285 (35291) 35291..35587 - 297 WP_001272251.1 hypothetical protein -
OH537_RS28290 (35887) 35887..36183 + 297 Protein_40 hypothetical protein -
OH537_RS28295 (36502) 36502..36627 - 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
OH537_RS28300 (36569) 36569..36718 - 150 Protein_42 plasmid maintenance protein Mok -
- (36704) 36704..36928 - 225 NuclAT_0 - Antitoxin
- (36704) 36704..36928 - 225 NuclAT_0 - Antitoxin
- (36704) 36704..36928 - 225 NuclAT_0 - Antitoxin
- (36704) 36704..36928 - 225 NuclAT_0 - Antitoxin
OH537_RS28305 (36940) 36940..37659 - 720 WP_001276217.1 plasmid SOS inhibition protein A -
OH537_RS28310 (37656) 37656..38090 - 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
OH537_RS28315 (38159) 38159..40182 - 2024 Protein_45 ParB/RepB/Spo0J family partition protein -
OH537_RS28320 (40243) 40243..40476 - 234 WP_000006003.1 DUF905 family protein -
OH537_RS28325 (40534) 40534..41061 - 528 WP_000290834.1 single-stranded DNA-binding protein -
OH537_RS28330 (41363) 41363..41830 + 468 Protein_48 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..154726 154726


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T261498 WP_001372321.1 NZ_CP107480:c36627-36502 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 225 bp

>AT261498 NZ_CP107480:c36928-36704 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References