Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3490286..3491061 Replicon chromosome
Accession NZ_CP107452
Organism Klebsiella pneumoniae strain CRKP_14

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OH499_RS17230 Protein ID WP_004150910.1
Coordinates 3490576..3491061 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OH499_RS17225 Protein ID WP_004150912.1
Coordinates 3490286..3490579 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH499_RS17205 3485494..3486096 - 603 WP_062954968.1 short chain dehydrogenase -
OH499_RS17210 3486194..3487105 + 912 WP_004188550.1 LysR family transcriptional regulator -
OH499_RS17215 3487106..3488254 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OH499_RS17220 3488265..3489641 - 1377 WP_004217775.1 cystathionine beta-synthase -
OH499_RS17225 3490286..3490579 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OH499_RS17230 3490576..3491061 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OH499_RS17235 3491765..3492358 + 594 WP_004188553.1 hypothetical protein -
OH499_RS17240 3492455..3492671 + 217 Protein_3368 transposase -
OH499_RS17245 3493277..3494149 + 873 WP_004188557.1 ParA family protein -
OH499_RS17250 3494149..3494532 + 384 WP_004150906.1 hypothetical protein -
OH499_RS17255 3494525..3495892 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3492455..3492607 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T261368 WP_004150910.1 NZ_CP107452:3490576-3491061 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT261368 WP_004150912.1 NZ_CP107452:3490286-3490579 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References