26127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2415580..2416097 Replicon chromosome
Accession NC_016941
Organism Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SAMSHR1132_RS11860 Protein ID WP_000113258.1
Coordinates 2415580..2415846 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag SAMSHR1132_RS11865 Protein ID WP_000635923.1
Coordinates 2415846..2416097 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMSHR1132_RS11835 2411013..2411549 - 537 WP_000169313.1 GNAT family N-acetyltransferase -
SAMSHR1132_RS11840 2411781..2412605 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAMSHR1132_RS11845 2412821..2413006 - 186 WP_000230291.1 hypothetical protein -
SAMSHR1132_RS11850 2413090..2413557 - 468 WP_000153336.1 SRPBCC domain-containing protein -
SAMSHR1132_RS11855 2413739..2415283 - 1545 WP_000727753.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAMSHR1132_RS11860 2415580..2415846 - 267 WP_000113258.1 Txe/YoeB family addiction module toxin Toxin
SAMSHR1132_RS11865 2415846..2416097 - 252 WP_000635923.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAMSHR1132_RS11870 2416369..2416968 - 600 WP_000162802.1 DsbA family protein -
SAMSHR1132_RS11875 2416988..2417350 - 363 WP_000826964.1 DUF4467 domain-containing protein -
SAMSHR1132_RS11880 2417604..2418854 + 1251 WP_001012242.1 aminoacyltransferase -
SAMSHR1132_RS11885 2418949..2419680 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
SAMSHR1132_RS11890 2419677..2420396 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10451.89 Da        Isoelectric Point: 9.7791

>T26127 WP_000113258.1 NC_016941:c2415846-2415580 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLSGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T26127 NC_016941:c2415846-2415580 [Staphylococcus argenteus]
ATGGCTAGGTTAAACATTACGTTCTCGCCTCAGGCATTTGAAGATTATGAGTATTTTCAGCAGAACGATAAAAAAATGGT
AAAGAAGATTAATGAGTTACTTAAAAGCATTGATAGAAATGGTGCATTGCAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATTTATCTGGCTATTATAGTAGACGTATCAATCACGAACATAGGTTGGTTTATACAGTTGACGATAATCACATAAAA
ATAGCATCCTGTAGATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9413.60 Da        Isoelectric Point: 4.3558

>AT26127 WP_000635923.1 NC_016941:c2416097-2415846 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSMIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT26127 NC_016941:c2416097-2415846 [Staphylococcus argenteus]
ATGATTGTAAAAAACTATTCTTACGCTAGACAGAATTTAAAGACGCTTATGACAAAGGTAAATGACGATAGTGATGTGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATTATGTCAGAAGCAGATTATAATTCTATGATTGAAACCCTTTACC
TTCAACAGAATCCAAATAATGCTGAACACTTAGCCCAATCAATTGCTGACTTAGAACGAGGCAAAATGGTAACGAAAGAA
ATAGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References