Detailed information of TA system TA026123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1974323..1974630
• Replicon: chromosome
• Accession: NC_016941
• Organism: Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAMSHR1132_RS13870
• Protein ID: WP_011447039.1
• Coordinates: 1974454..1974630 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1974323..1974462 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMSHR1132_RS09495	1969889..1970068	+	180	WP_000669789.1	hypothetical protein	-
SAMSHR1132_RS09505	1970379..1970639	+	261	WP_001791826.1	hypothetical protein	-
SAMSHR1132_RS09510	1970692..1971042	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SAMSHR1132_RS13855	1971553..1971888	-	336	Protein_1809	SH3 domain-containing protein	-
SAMSHR1132_RS09520	1972539..1973030	-	492	WP_000920035.1	staphylokinase	-
SAMSHR1132_RS09525	1973221..1973976	-	756	WP_000861030.1	CHAP domain-containing protein	-
SAMSHR1132_RS09530	1973988..1974242	-	255	WP_000611512.1	phage holin	-
SAMSHR1132_RS09535	1974294..1974401	+	108	WP_001791821.1	hypothetical protein	-
-	1974323..1974462	+	140	NuclAT_0	-	Antitoxin
-	1974323..1974462	+	140	NuclAT_0	-	Antitoxin
-	1974323..1974462	+	140	NuclAT_0	-	Antitoxin
-	1974323..1974462	+	140	NuclAT_0	-	Antitoxin
SAMSHR1132_RS13870	1974454..1974630	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAMSHR1132_RS09545	1974780..1975076	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAMSHR1132_RS09550	1975134..1975421	-	288	WP_001040256.1	hypothetical protein	-
SAMSHR1132_RS09555	1975468..1975620	-	153	WP_001153681.1	hypothetical protein	-
SAMSHR1132_RS09560	1975610..1979395	-	3786	WP_000582188.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1970692..2021617	50925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T26123 WP_011447039.1 NC_016941:c1974630-1974454 [Staphylococcus argenteus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26123 NC_016941:c1974630-1974454 [Staphylococcus argenteus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT26123 NC_016941:1974323-1974462 [Staphylococcus argenteus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin