Detailed information of TA system TA261175

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 115105..115531
• Replicon: plasmid unnamed2
• Accession: NZ_CP107414
• Organism: Klebsiella pneumoniae strain CRKP_22

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: OH525_RS28530
• Protein ID: WP_001372321.1
• Coordinates: 115406..115531 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	115105..115329 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OH525_RS28495 (110209)	110209..110670	-	462	Protein_142	hypothetical protein	-
OH525_RS28500 (110972)	110972..111499	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
OH525_RS28505 (111557)	111557..111790	+	234	WP_000006003.1	DUF905 family protein	-
OH525_RS28510 (111851)	111851..113874	+	2024	Protein_145	ParB/RepB/Spo0J family partition protein	-
OH525_RS28515 (113943)	113943..114377	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
OH525_RS28520 (114374)	114374..115093	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
- (115105)	115105..115329	+	225	NuclAT_0	-	Antitoxin
- (115105)	115105..115329	+	225	NuclAT_0	-	Antitoxin
- (115105)	115105..115329	+	225	NuclAT_0	-	Antitoxin
- (115105)	115105..115329	+	225	NuclAT_0	-	Antitoxin
OH525_RS28525 (115315)	115315..115464	+	150	Protein_148	plasmid maintenance protein Mok	-
OH525_RS28530 (115406)	115406..115531	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
OH525_RS28535 (115850)	115850..116146	-	297	Protein_150	hypothetical protein	-
OH525_RS28540 (116446)	116446..116742	+	297	WP_001272251.1	hypothetical protein	-
OH525_RS28545 (116853)	116853..117674	+	822	WP_001234445.1	DUF932 domain-containing protein	-
OH525_RS28550 (117971)	117971..118618	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
OH525_RS28555 (118895)	118895..119278	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
OH525_RS28560 (119469)	119469..120155	+	687	WP_015059009.1	PAS domain-containing protein	-
OH525_RS28565 (120249)	120249..120476	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB	-	1..146158	146158

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T261175 WP_001372321.1 NZ_CP107414:115406-115531 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT261175 NZ_CP107414:115105-115329 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin