Detailed information of TA system TA026115

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2462562..2462746
• Replicon: chromosome
• Accession: NC_016928
• Organism: Staphylococcus aureus subsp. aureus M013

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M013TW_RS12395
• Protein ID: WP_000482647.1
• Coordinates: 2462639..2462746 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2462562..2462622 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M013TW_RS12380	2458072..2458239	-	168	WP_031845053.1	hypothetical protein	-
M013TW_RS12385	2458470..2460203	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
M013TW_RS12390	2460279..2461991	-	1713	WP_001064821.1	ABC transporter ATP-binding protein/permease	-
M013TW_RS14135	2462445..2462612	-	168	WP_000301893.1	hypothetical protein	-
-	2462562..2462622	+	61	-	-	Antitoxin
M013TW_RS12395	2462639..2462746	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M013TW_RS12400	2462879..2463265	-	387	WP_000779353.1	flippase GtxA	-
M013TW_RS12405	2463533..2464675	+	1143	WP_001176863.1	glycerate kinase	-
M013TW_RS12410	2464735..2465394	+	660	WP_000831298.1	membrane protein	-
M013TW_RS12415	2465577..2466788	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
M013TW_RS12420	2466911..2467384	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T26115 WP_000482647.1 NC_016928:c2462746-2462639 [Staphylococcus aureus subsp. aureus M013]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T26115 NC_016928:c2462746-2462639 [Staphylococcus aureus subsp. aureus M013]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT26115 NC_016928:2462562-2462622 [Staphylococcus aureus subsp. aureus M013]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin