Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1567098..1567512 Replicon chromosome
Accession NC_016928
Organism Staphylococcus aureus subsp. aureus M013

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M013TW_RS07560 Protein ID WP_001065099.1
Coordinates 1567261..1567512 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M013TW_RS14170 Protein ID WP_000028424.1
Coordinates 1567098..1567271 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M013TW_RS07505 1562880..1563224 - 345 WP_000402904.1 hypothetical protein -
M013TW_RS07510 1563355..1563654 - 300 WP_000988330.1 HNH endonuclease -
M013TW_RS07515 1563886..1564302 - 417 WP_000590123.1 hypothetical protein -
M013TW_RS07520 1564330..1564530 - 201 WP_000265043.1 DUF1514 family protein -
M013TW_RS07525 1564530..1565180 - 651 WP_001005262.1 hypothetical protein -
M013TW_RS07530 1565339..1565488 - 150 WP_000237868.1 transcriptional activator RinB -
M013TW_RS07535 1565491..1565691 - 201 WP_001125015.1 hypothetical protein -
M013TW_RS07540 1565666..1565854 - 189 WP_000195782.1 DUF1381 domain-containing protein -
M013TW_RS07545 1565851..1566096 - 246 WP_001282074.1 hypothetical protein -
M013TW_RS07550 1566133..1566639 - 507 WP_001061834.1 dUTPase -
M013TW_RS14165 1566654..1566815 - 162 WP_000889683.1 hypothetical protein -
M013TW_RS07555 1566816..1567097 - 282 WP_000454994.1 hypothetical protein -
M013TW_RS14170 1567098..1567271 - 174 WP_000028424.1 hypothetical protein Antitoxin
M013TW_RS07560 1567261..1567512 - 252 WP_001065099.1 DUF1024 family protein Toxin
M013TW_RS07565 1567527..1567769 - 243 WP_000131388.1 phi PVL orf 51-like protein -
M013TW_RS07570 1567773..1568129 - 357 WP_000029366.1 hypothetical protein -
M013TW_RS07575 1568130..1568315 - 186 WP_001187236.1 DUF3113 family protein -
M013TW_RS07580 1568320..1568724 - 405 WP_000049798.1 DUF1064 domain-containing protein -
M013TW_RS07585 1568734..1568955 - 222 WP_001123669.1 DUF3269 family protein -
M013TW_RS07590 1568968..1569126 - 159 WP_000256594.1 hypothetical protein -
M013TW_RS07595 1569120..1569899 - 780 WP_000803062.1 ATP-binding protein -
M013TW_RS07600 1569909..1570679 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
M013TW_RS07605 1570745..1571026 + 282 WP_000414755.1 hypothetical protein -
M013TW_RS14175 1571019..1571168 - 150 WP_001081076.1 hypothetical protein -
M013TW_RS07610 1571165..1571839 - 675 WP_000057262.1 hypothetical protein -
M013TW_RS07615 1571851..1572294 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1537480..1599370 61890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T26109 WP_001065099.1 NC_016928:c1567512-1567261 [Staphylococcus aureus subsp. aureus M013]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T26109 NC_016928:c1567512-1567261 [Staphylococcus aureus subsp. aureus M013]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT26109 WP_000028424.1 NC_016928:c1567271-1567098 [Staphylococcus aureus subsp. aureus M013]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT26109 NC_016928:c1567271-1567098 [Staphylococcus aureus subsp. aureus M013]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References