Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2405246..2405769 Replicon chromosome
Accession NC_016912
Organism Staphylococcus aureus subsp. aureus VC40

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAVC_RS12215 Protein ID WP_000074048.1
Coordinates 2405246..2405512 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SAVC_RS12220 Protein ID WP_000587616.1
Coordinates 2405512..2405769 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAVC_RS12195 2400553..2401740 - 1188 WP_000026194.1 MFS transporter -
SAVC_RS12200 2402136..2402912 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
SAVC_RS12205 2402905..2403567 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
SAVC_RS12210 2403815..2404891 - 1077 WP_001076671.1 M42 family metallopeptidase -
SAVC_RS12215 2405246..2405512 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAVC_RS12220 2405512..2405769 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAVC_RS12230 2406128..2406583 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SAVC_RS12235 2406751..2408328 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
SAVC_RS12240 2408523..2409272 + 750 WP_000072443.1 hypothetical protein -
SAVC_RS12245 2409496..2410689 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T26105 WP_000074048.1 NC_016912:c2405512-2405246 [Staphylococcus aureus subsp. aureus VC40]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T26105 NC_016912:c2405512-2405246 [Staphylococcus aureus subsp. aureus VC40]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT26105 WP_000587616.1 NC_016912:c2405769-2405512 [Staphylococcus aureus subsp. aureus VC40]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT26105 NC_016912:c2405769-2405512 [Staphylococcus aureus subsp. aureus VC40]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References