Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2373746..2373930 Replicon chromosome
Accession NC_016912
Organism Staphylococcus aureus subsp. aureus VC40

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag SAVC_RS12060 Protein ID WP_000482650.1
Coordinates 2373823..2373930 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2373746..2373806 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAVC_RS12035 2369276..2369443 - 168 WP_001790576.1 hypothetical protein -
SAVC_RS12045 2369674..2371407 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SAVC_RS12050 2371432..2373195 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2373746..2373806 + 61 - - Antitoxin
SAVC_RS12060 2373823..2373930 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
SAVC_RS12065 2374064..2374450 - 387 WP_000779358.1 flippase GtxA -
SAVC_RS12070 2374718..2375860 + 1143 WP_001176863.1 glycerate kinase -
SAVC_RS12075 2375920..2376579 + 660 WP_000831298.1 membrane protein -
SAVC_RS12080 2376761..2377972 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAVC_RS12085 2378095..2378568 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T26103 WP_000482650.1 NC_016912:c2373930-2373823 [Staphylococcus aureus subsp. aureus VC40]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T26103 NC_016912:c2373930-2373823 [Staphylococcus aureus subsp. aureus VC40]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT26103 NC_016912:2373746-2373806 [Staphylococcus aureus subsp. aureus VC40]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References