Detailed information of TA system TA026102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2348394..2348911
• Replicon: chromosome
• Accession: NC_016912
• Organism: Staphylococcus aureus subsp. aureus VC40

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: SAVC_RS11905
• Protein ID: WP_000113262.1
• Coordinates: 2348394..2348660 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: SAVC_RS11910
• Protein ID: WP_000584499.1
• Coordinates: 2348660..2348911 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAVC_RS11880	2343820..2344356	-	537	WP_000169315.1	GNAT family N-acetyltransferase	-
SAVC_RS11885	2344589..2345413	-	825	WP_000572040.1	formate/nitrite transporter family protein	-
SAVC_RS11890	2345630..2345812	-	183	WP_000230294.1	hypothetical protein	-
SAVC_RS11895	2345896..2346363	-	468	WP_000153344.1	SRPBCC domain-containing protein	-
SAVC_RS11900	2346549..2348099	-	1551	WP_000727762.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
SAVC_RS14390	2348288..2348359	-	72	Protein_2233	hypothetical protein	-
SAVC_RS11905	2348394..2348660	-	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
SAVC_RS11910	2348660..2348911	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SAVC_RS11915	2349076..2349177	-	102	WP_001791744.1	hypothetical protein	-
SAVC_RS11920	2349184..2349783	-	600	WP_000162813.1	DsbA family protein	-
SAVC_RS11925	2349802..2350164	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
SAVC_RS11930	2350419..2351669	+	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
SAVC_RS11935	2351766..2352497	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
SAVC_RS11940	2352494..2353213	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T26102 WP_000113262.1 NC_016912:c2348660-2348394 [Staphylococcus aureus subsp. aureus VC40]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T26102 NC_016912:c2348660-2348394 [Staphylococcus aureus subsp. aureus VC40]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT26102 WP_000584499.1 NC_016912:c2348911-2348660 [Staphylococcus aureus subsp. aureus VC40]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT26102 NC_016912:c2348911-2348660 [Staphylococcus aureus subsp. aureus VC40]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60