Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2083244..2083507 Replicon chromosome
Accession NC_016912
Organism Staphylococcus aureus subsp. aureus VC40

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAVC_RS10485 Protein ID WP_001802298.1
Coordinates 2083403..2083507 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2083244..2083408 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAVC_RS10465 2079484..2080149 - 666 WP_001024094.1 SDR family oxidoreductase -
SAVC_RS10470 2080301..2080621 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAVC_RS10475 2080623..2081603 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
SAVC_RS10480 2081869..2082960 + 1092 WP_000495671.1 lytic regulatory protein -
- 2083244..2083408 + 165 - - Antitoxin
SAVC_RS10485 2083403..2083507 - 105 WP_001802298.1 hypothetical protein Toxin
SAVC_RS14370 2083668..2084151 - 484 Protein_1967 recombinase family protein -
SAVC_RS10495 2084194..2085330 - 1137 WP_000115562.1 SAP domain-containing protein -
SAVC_RS10500 2085619..2085711 + 93 WP_001790138.1 hypothetical protein -
SAVC_RS10505 2086416..2087273 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
SAVC_RS10510 2087341..2088123 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T26101 WP_001802298.1 NC_016912:c2083507-2083403 [Staphylococcus aureus subsp. aureus VC40]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T26101 NC_016912:c2083507-2083403 [Staphylococcus aureus subsp. aureus VC40]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT26101 NC_016912:2083244-2083408 [Staphylococcus aureus subsp. aureus VC40]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References