Detailed information of TA system TA026093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1257706..1258221
• Replicon: chromosome
• Accession: NC_016906
• Organism: Gordonia polyisoprenivorans VH2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: H6N1E8
• Locus tag: GPOL_RS05495
• Protein ID: WP_014359060.1
• Coordinates: 1257967..1258221 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: H6N1E7
• Locus tag: GPOL_RS05490
• Protein ID: WP_014359059.1
• Coordinates: 1257706..1257966 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPOL_RS05475	1253539..1254606	-	1068	WP_014359056.1	PrsW family intramembrane metalloprotease	-
GPOL_RS05480	1254798..1257086	-	2289	WP_014359057.1	hypothetical protein	-
GPOL_RS05485	1257083..1257421	-	339	WP_014359058.1	hypothetical protein	-
GPOL_RS05490	1257706..1257966	+	261	WP_014359059.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GPOL_RS05495	1257967..1258221	+	255	WP_014359060.1	Txe/YoeB family addiction module toxin	Toxin
GPOL_RS05500	1258343..1259827	+	1485	WP_014359061.1	aryl-sulfate sulfotransferase	-
GPOL_RS26275	1259992..1261221	+	1230	Protein_1102	mycolyltransferase	-
GPOL_RS05505	1261231..1262304	-	1074	WP_014359062.1	phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9911.29 Da
• Isoelectric Point: 7.2745

>T26093 WP_014359060.1 NC_016906:1257967-1258221 [Gordonia polyisoprenivorans VH2]
VRLVWDQSAWEDYVHWQTADRRLLKRINTLLDACLRDAFTGIGKPEPLKYGVPGAWSRRISDEHRLVYLVDGDDVIILQA
RYHY

Nucleotide

• Length: 255 bp

>T26093 NC_016906:1257967-1258221 [Gordonia polyisoprenivorans VH2]
GTGCGTCTGGTCTGGGACCAATCGGCATGGGAAGACTATGTGCACTGGCAAACCGCTGACCGGCGACTACTGAAGCGGAT
CAACACGCTGCTCGACGCGTGCCTGCGCGATGCATTCACTGGCATCGGAAAACCCGAACCGCTCAAGTACGGAGTCCCGG
GTGCCTGGTCGCGGCGCATCTCCGACGAACACCGGCTCGTCTACCTCGTCGATGGCGATGACGTGATCATTCTGCAGGCC
CGGTACCACTACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9675.74 Da
• Isoelectric Point: 4.4678

>AT26093 WP_014359059.1 NC_016906:1257706-1257966 [Gordonia polyisoprenivorans VH2]
MSISASEARKLLFPLIEQVNDDRSAIEIVSRKGNAVLMSADEYAAWQETAYLFRSPANARRLLESYTRVSVGQTEVHDLD
RTDEDG

Nucleotide

• Length: 261 bp

>AT26093 NC_016906:1257706-1257966 [Gordonia polyisoprenivorans VH2]
ATGTCTATCAGTGCGAGTGAGGCGCGGAAGTTGCTGTTTCCGCTGATCGAGCAGGTCAACGACGATCGGAGTGCGATCGA
AATCGTGTCTCGGAAGGGCAATGCGGTGCTGATGTCGGCCGACGAGTACGCGGCGTGGCAGGAGACGGCCTACCTGTTCA
GGTCGCCGGCCAACGCCCGCCGACTGTTGGAGTCCTACACACGTGTCTCCGTGGGGCAGACCGAGGTGCATGACCTCGAC
CGGACCGACGAGGACGGCTGA

Structures

Toxin

• AlphaFold DB: H6N1E8

Antitoxin

• AlphaFold DB: H6N1E7