Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2951474..2952120 Replicon chromosome
Accession NZ_CP107352
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag OH515_RS14095 Protein ID WP_004188313.1
Coordinates 2951474..2951821 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OH515_RS14100 Protein ID WP_135695834.1
Coordinates 2951821..2952120 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS14085 (2947400) 2947400..2948833 + 1434 WP_002920564.1 glycogen synthase GlgA -
OH515_RS14090 (2948851) 2948851..2951298 + 2448 WP_002920561.1 glycogen phosphorylase -
OH515_RS14095 (2951474) 2951474..2951821 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH515_RS14100 (2951821) 2951821..2952120 + 300 WP_135695834.1 helix-turn-helix transcriptional regulator Antitoxin
OH515_RS14105 (2952183) 2952183..2953691 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
OH515_RS14110 (2953896) 2953896..2954225 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
OH515_RS14115 (2954276) 2954276..2955106 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
OH515_RS14120 (2955156) 2955156..2955914 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T260879 WP_004188313.1 NZ_CP107352:2951474-2951821 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.58 Da        Isoelectric Point: 10.1464

>AT260879 WP_135695834.1 NZ_CP107352:2951821-2952120 [Klebsiella pneumoniae]
MSTLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure

References