Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 31914..32340 Replicon plasmid unnamed2
Accession NZ_CP107347
Organism Klebsiella pneumoniae strain CRKP_36

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag OH497_RS28210 Protein ID WP_001372321.1
Coordinates 31914..32039 (-) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 32116..32340 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH497_RS28180 (27182) 27182..27886 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
OH497_RS28185 (28167) 28167..28550 - 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
OH497_RS28190 (28827) 28827..29474 + 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
OH497_RS28195 (29771) 29771..30592 - 822 WP_001234445.1 DUF932 domain-containing protein -
OH497_RS28200 (30703) 30703..30999 - 297 WP_001272251.1 hypothetical protein -
OH497_RS28205 (31299) 31299..31595 + 297 Protein_40 hypothetical protein -
OH497_RS28210 (31914) 31914..32039 - 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
OH497_RS28215 (31981) 31981..32130 - 150 Protein_42 plasmid maintenance protein Mok -
- (32116) 32116..32340 - 225 NuclAT_0 - Antitoxin
- (32116) 32116..32340 - 225 NuclAT_0 - Antitoxin
- (32116) 32116..32340 - 225 NuclAT_0 - Antitoxin
- (32116) 32116..32340 - 225 NuclAT_0 - Antitoxin
OH497_RS28220 (32352) 32352..33071 - 720 WP_001276217.1 plasmid SOS inhibition protein A -
OH497_RS28225 (33068) 33068..33502 - 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
OH497_RS28230 (33571) 33571..35594 - 2024 Protein_45 ParB/RepB/Spo0J family partition protein -
OH497_RS28235 (35655) 35655..35888 - 234 WP_000006003.1 DUF905 family protein -
OH497_RS28240 (35946) 35946..36473 - 528 WP_000290834.1 single-stranded DNA-binding protein -
OH497_RS28245 (36775) 36775..37224 + 450 Protein_48 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaKPC-2 / blaSHV-12 / rmtB / blaTEM-1B / blaCTX-M-65 - 1..134594 134594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T260864 WP_001372321.1 NZ_CP107347:c32039-31914 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 225 bp

>AT260864 NZ_CP107347:c32340-32116 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References