Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 56133..56860 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP107346 | ||
| Organism | Klebsiella pneumoniae strain CRKP_36 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | OH497_RS27250 | Protein ID | WP_011251285.1 |
| Coordinates | 56133..56444 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OH497_RS27255 | Protein ID | WP_011251286.1 |
| Coordinates | 56441..56860 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OH497_RS27220 | 52633..52863 | + | 231 | WP_011154571.1 | hypothetical protein | - |
| OH497_RS27225 | 53146..53310 | - | 165 | Protein_64 | Tn3 family transposase | - |
| OH497_RS27230 | 53448..53927 | + | 480 | WP_004212799.1 | cyclophilin-like fold protein | - |
| OH497_RS27235 | 53924..54724 | + | 801 | WP_228722687.1 | aldo/keto reductase | - |
| OH497_RS27245 | 55491..55928 | + | 438 | Protein_68 | DDE-type integrase/transposase/recombinase | - |
| OH497_RS27250 | 56133..56444 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OH497_RS27255 | 56441..56860 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| OH497_RS27260 | 57007..57975 | + | 969 | WP_086642568.1 | IS5 family transposase | - |
| OH497_RS27265 | 58047..58412 | - | 366 | WP_048333448.1 | hypothetical protein | - |
| OH497_RS27270 | 58426..59214 | - | 789 | WP_040217257.1 | hypothetical protein | - |
| OH497_RS27275 | 59235..59855 | - | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| OH497_RS27280 | 60274..60909 | + | 636 | WP_223171879.1 | hypothetical protein | - |
| OH497_RS27285 | 61222..61692 | + | 471 | WP_048333570.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA / iroN / rmpA2 / iutA / iucD / iucC / iucB / iucA | 1..193834 | 193834 | |
| - | inside | IScluster/Tn | - | - | 54659..74615 | 19956 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T260861 WP_011251285.1 NZ_CP107346:56133-56444 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT260861 WP_011251286.1 NZ_CP107346:56441-56860 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|