260730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3494884..3495659 Replicon chromosome
Accession NZ_CP107312
Organism Klebsiella pneumoniae strain CRKP_41

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OH506_RS17280 Protein ID WP_004150910.1
Coordinates 3495174..3495659 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OH506_RS17275 Protein ID WP_004150912.1
Coordinates 3494884..3495177 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH506_RS17255 3490092..3490694 - 603 WP_062954968.1 short chain dehydrogenase -
OH506_RS17260 3490792..3491703 + 912 WP_004188550.1 LysR family transcriptional regulator -
OH506_RS17265 3491704..3492852 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OH506_RS17270 3492863..3494239 - 1377 WP_004217775.1 cystathionine beta-synthase -
OH506_RS17275 3494884..3495177 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OH506_RS17280 3495174..3495659 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OH506_RS17285 3496363..3496956 + 594 WP_004188553.1 hypothetical protein -
OH506_RS17290 3497053..3497269 + 217 Protein_3378 transposase -
OH506_RS17295 3497875..3498747 + 873 WP_004188557.1 ParA family protein -
OH506_RS17300 3498747..3499130 + 384 WP_004150906.1 hypothetical protein -
OH506_RS17305 3499123..3500490 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3497053..3497205 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T260730 WP_004150910.1 NZ_CP107312:3495174-3495659 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT260730 WP_004150912.1 NZ_CP107312:3494884-3495177 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References