Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 23789..24215 | Replicon | plasmid unnamed2 |
Accession | NZ_CP107299 | ||
Organism | Klebsiella pneumoniae strain CRKP_44 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | OH517_RS28815 | Protein ID | WP_001372321.1 |
Coordinates | 24090..24215 (+) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 23789..24013 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OH517_RS28780 (18899) | 18899..19354 | - | 456 | Protein_25 | hypothetical protein | - |
OH517_RS28785 (19656) | 19656..20183 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
OH517_RS28790 (20241) | 20241..20474 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
OH517_RS28795 (20535) | 20535..22558 | + | 2024 | Protein_28 | ParB/RepB/Spo0J family partition protein | - |
OH517_RS28800 (22627) | 22627..23061 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
OH517_RS28805 (23058) | 23058..23777 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- (23789) | 23789..24013 | + | 225 | NuclAT_0 | - | Antitoxin |
- (23789) | 23789..24013 | + | 225 | NuclAT_0 | - | Antitoxin |
- (23789) | 23789..24013 | + | 225 | NuclAT_0 | - | Antitoxin |
- (23789) | 23789..24013 | + | 225 | NuclAT_0 | - | Antitoxin |
OH517_RS28810 (23999) | 23999..24148 | + | 150 | Protein_31 | plasmid maintenance protein Mok | - |
OH517_RS28815 (24090) | 24090..24215 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
OH517_RS28820 (24534) | 24534..24830 | - | 297 | Protein_33 | hypothetical protein | - |
OH517_RS28825 (25130) | 25130..25426 | + | 297 | WP_001272251.1 | hypothetical protein | - |
OH517_RS28830 (25537) | 25537..26358 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
OH517_RS28835 (26655) | 26655..27302 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
OH517_RS28840 (27579) | 27579..27962 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
OH517_RS28845 (28153) | 28153..28839 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
OH517_RS28850 (28933) | 28933..29160 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 / blaCTX-M-65 / tet(A) / blaLAP-2 / qnrS1 / dfrA14 / sul2 / fosA3 | - | 1..215446 | 215446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T260672 WP_001372321.1 NZ_CP107299:24090-24215 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 225 bp
>AT260672 NZ_CP107299:23789-24013 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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