Detailed information of TA system TA026062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4255220..4255822
• Accession: NC_016856
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: STM14_RS21215
• Protein ID: WP_001159630.1
• Coordinates: 4255220..4255531 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: STM14_RS21220
• Protein ID: WP_000362050.1
• Coordinates: 4255532..4255822 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STM14_RS21180 (STM14_4840)	4250333..4250932	+	600	WP_000965695.1	glucose-1-phosphatase	-
STM14_RS21185 (STM14_4841)	4250926..4251798	+	873	WP_000921427.1	virulence factor BrkB family protein	-
STM14_RS21190 (STM14_4842)	4251795..4252232	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
STM14_RS21195 (STM14_4843)	4252277..4253218	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
STM14_RS21200 (STM14_4844)	4253233..4253679	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
STM14_RS21205 (STM14_4845)	4253676..4253987	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
STM14_RS21210 (STM14_4846)	4254073..4255002	-	930	WP_001127703.1	alpha/beta hydrolase	-
STM14_RS21215 (STM14_4847)	4255220..4255531	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
STM14_RS21220 (STM14_4848)	4255532..4255822	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
STM14_RS21225 (STM14_4849)	4255869..4256798	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
STM14_RS21230 (STM14_4850)	4256795..4257430	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
STM14_RS21235 (STM14_4851)	4257427..4258329	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T26062 WP_001159630.1 NC_016856:4255220-4255531 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T26062 NC_016856:4255220-4255531 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT26062 WP_000362050.1 NC_016856:4255532-4255822 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT26062 NC_016856:4255532-4255822 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64