Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4191406..4191664 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag OF379_RS20185 Protein ID WP_000809168.1
Coordinates 4191512..4191664 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4191406..4191463 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS20170 4187798..4188757 + 960 WP_000871682.1 hypothetical protein -
OF379_RS20175 4188795..4189694 - 900 WP_001300855.1 transcriptional activator NhaR -
OF379_RS20180 4189760..4190926 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4191406..4191463 - 58 - - Antitoxin
OF379_RS20185 4191512..4191664 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
OF379_RS20190 4191768..4192898 - 1131 WP_001118464.1 molecular chaperone DnaJ -
OF379_RS20195 4192987..4194903 - 1917 WP_000516135.1 molecular chaperone DnaK -
OF379_RS20200 4195279..4195683 + 405 WP_000843579.1 DUF2541 family protein -
OF379_RS20205 4195709..4196422 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T260618 WP_000809168.1 NZ_CP107284:4191512-4191664 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT260618 NZ_CP107284:c4191463-4191406 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References