Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 628286..629085 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7B2BI69
Locus tag OF379_RS02990 Protein ID WP_000347258.1
Coordinates 628286..628750 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A368IY36
Locus tag OF379_RS02995 Protein ID WP_001604880.1
Coordinates 628750..629085 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS02960 (623287) 623287..623721 - 435 WP_000948829.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OF379_RS02965 (623739) 623739..624617 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
OF379_RS02970 (624607) 624607..625386 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
OF379_RS02975 (625397) 625397..625870 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
OF379_RS02980 (625893) 625893..627173 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
OF379_RS02985 (627422) 627422..628231 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
OF379_RS02990 (628286) 628286..628750 - 465 WP_000347258.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OF379_RS02995 (628750) 628750..629085 - 336 WP_001604880.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OF379_RS03000 (629234) 629234..630805 - 1572 WP_001273737.1 galactarate dehydratase -
OF379_RS03005 (631180) 631180..632514 + 1335 WP_000599654.1 galactarate/glucarate/glycerate transporter GarP -
OF379_RS03010 (632530) 632530..633300 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.32 Da        Isoelectric Point: 9.6924

>T260606 WP_000347258.1 NZ_CP107284:c628750-628286 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEILKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12340.91 Da        Isoelectric Point: 4.8616

>AT260606 WP_001604880.1 NZ_CP107284:c629085-628750 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGLDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7B2BI69

Antitoxin

Source ID Structure
AlphaFold DB A0A368IY36

References