Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2291985..2292666 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag PALA22_RS10680 Protein ID WP_003111825.1
Coordinates 2291985..2292350 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag PALA22_RS10685 Protein ID WP_003159602.1
Coordinates 2292343..2292666 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS10650 (PALA22_02115) 2287949..2288383 - 435 WP_003158601.1 RidA family protein -
PALA22_RS10655 (PALA22_02116) 2288604..2289557 + 954 WP_034012959.1 LysR substrate-binding domain-containing protein -
PALA22_RS10660 (PALA22_02117) 2289530..2290414 - 885 WP_034012956.1 LysR family transcriptional regulator -
PALA22_RS10665 (PALA22_02118) 2290515..2290940 + 426 WP_003158599.1 VOC family protein -
PALA22_RS10670 (PALA22_02119) 2290971..2291243 - 273 WP_003085667.1 hypothetical protein -
PALA22_RS10675 2291450..2291692 + 243 WP_043884955.1 hypothetical protein -
PALA22_RS10680 2291985..2292350 + 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA22_RS10685 (PALA22_02120) 2292343..2292666 + 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
PALA22_RS10690 (PALA22_02121) 2293042..2294130 - 1089 WP_031652783.1 DUF3396 domain-containing protein -
PALA22_RS10695 (PALA22_02122) 2294147..2294848 - 702 WP_030046795.1 VRR-NUC domain-containing protein -
PALA22_RS10700 (PALA22_02123) 2294845..2295363 - 519 WP_034012953.1 PAAR domain-containing protein -
PALA22_RS10705 (PALA22_02124) 2295537..2295872 - 336 WP_263919420.1 TM2 domain-containing protein -
PALA22_RS10710 (PALA22_02125) 2296115..2296753 - 639 WP_034012950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2234585..2295872 61287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T260596 WP_003111825.1 NZ_CP107275:2291985-2292350 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT260596 WP_003159602.1 NZ_CP107275:2292343-2292666 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References