Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1551117..1551712 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA22_RS07155 Protein ID WP_003113526.1
Coordinates 1551117..1551395 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA22_RS07160 Protein ID WP_003099268.1
Coordinates 1551407..1551712 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS07135 (PALA22_01420) 1546543..1547781 + 1239 WP_017001387.1 C69 family dipeptidase -
PALA22_RS07140 (PALA22_01421) 1547843..1548490 + 648 WP_003095021.1 carbonate dehydratase -
PALA22_RS07145 (PALA22_01422) 1548560..1550788 - 2229 WP_003113525.1 TonB-dependent receptor -
PALA22_RS07150 1550936..1551064 + 129 Protein_1409 integrase -
PALA22_RS07155 1551117..1551395 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA22_RS07160 (PALA22_01423) 1551407..1551712 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA22_RS07170 (PALA22_01425) 1552118..1553218 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA22_RS07175 (PALA22_01426) 1553259..1553843 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA22_RS07180 (PALA22_01427) 1553885..1554499 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA22_RS07185 (PALA22_01428) 1554616..1555557 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA22_RS07195 (PALA22_01430) 1555724..1556572 - 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T260595 WP_003113526.1 NZ_CP107275:1551117-1551395 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT260595 WP_003099268.1 NZ_CP107275:1551407-1551712 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References