Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/-
Location 3693591..3694129 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag STM14_RS18645 Protein ID WP_001526148.1
Coordinates 3693591..3693866 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag STM14_RS18650 Protein ID WP_000729713.1
Coordinates 3693869..3694129 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS18640 (STM14_4234) 3690798..3693503 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
STM14_RS18645 (STM14_4235) 3693591..3693866 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
STM14_RS18650 (STM14_4236) 3693869..3694129 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
STM14_RS18655 (STM14_4237) 3694238..3695257 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
STM14_RS18660 (STM14_4238) 3695261..3696475 - 1215 WP_001105521.1 RNA-splicing ligase RtcB -
STM14_RS18665 (STM14_4239) 3696823..3698376 - 1554 WP_000013008.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T26058 WP_001526148.1 NC_016856:c3693866-3693591 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T26058 NC_016856:c3693866-3693591 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT26058 WP_000729713.1 NC_016856:c3694129-3693869 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT26058 NC_016856:c3694129-3693869 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References