Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2597400..2598046 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5937_RS12990 Protein ID WP_103177685.1
Coordinates 2597400..2597750 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5937_RS12995 Protein ID WP_103177684.1
Coordinates 2597747..2598046 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS12960 (2594105) 2594105..2594275 - 171 WP_164725120.1 hypothetical protein -
N5937_RS12965 (2594554) 2594554..2595312 + 759 WP_263950098.1 WYL domain-containing protein -
N5937_RS12970 (2595326) 2595326..2595517 - 192 WP_263950099.1 toxin-antitoxin system HicB family antitoxin -
N5937_RS12975 (2595642) 2595642..2595929 + 288 WP_263950100.1 SymE family type I addiction module toxin -
N5937_RS12980 (2596168) 2596168..2596779 + 612 WP_263950101.1 hypothetical protein -
N5937_RS12985 (2596852) 2596852..2597289 - 438 WP_263950102.1 acetyltransferase -
N5937_RS12990 (2597400) 2597400..2597750 + 351 WP_103177685.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5937_RS12995 (2597747) 2597747..2598046 + 300 WP_103177684.1 XRE family transcriptional regulator Antitoxin
N5937_RS13000 (2598141) 2598141..2598665 - 525 WP_103177683.1 lipocalin family protein -
N5937_RS13005 (2598783) 2598783..2599511 + 729 WP_263950103.1 MerR family transcriptional regulator -
N5937_RS13010 (2599608) 2599608..2600018 + 411 WP_114385495.1 hydroxyisourate hydrolase -
N5937_RS13015 (2600121) 2600121..2601080 + 960 WP_103177681.1 DUF523 and DUF1722 domain-containing protein -
N5937_RS13020 (2601225) 2601225..2602313 + 1089 WP_159340366.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2594105..2605888 11783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13547.46 Da        Isoelectric Point: 7.2761

>T260575 WP_103177685.1 NZ_CP107262:2597400-2597750 [Leclercia adecarboxylata]
MWTVILGEVFEAWLEDQEQGVQEKVFAALINLQTYGPRLPRPYADTVRGSRHNNMKELRIQYYGRPIRAFFAFDPVRQAI
VLCAGDKSHDKKFYERLIRIADDEFSAHLAAMETRN

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11208.12 Da        Isoelectric Point: 8.6049

>AT260575 WP_103177684.1 NZ_CP107262:2597747-2598046 [Leclercia adecarboxylata]
MKTLNEAIASRSPESQKRIKEMADEMILETGLQMMREELKLSQKHVAEVMGISQPAITQLEQRGNELKITTLKRYIEAMG
GKLSLDVELPNGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References