Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1320735..1321384 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5937_RS06830 Protein ID WP_103178551.1
Coordinates 1320735..1321097 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5937_RS06835 Protein ID WP_103178550.1
Coordinates 1321085..1321384 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS06810 (1316018) 1316018..1316992 - 975 WP_103178554.1 LacI family DNA-binding transcriptional regulator -
N5937_RS06815 (1317068) 1317068..1318210 - 1143 WP_263951222.1 Gfo/Idh/MocA family oxidoreductase -
N5937_RS06820 (1318203) 1318203..1319228 - 1026 WP_263951223.1 sugar phosphate isomerase/epimerase -
N5937_RS06825 (1319243) 1319243..1320481 - 1239 WP_103181038.1 MFS transporter -
N5937_RS06830 (1320735) 1320735..1321097 + 363 WP_103178551.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5937_RS06835 (1321085) 1321085..1321384 + 300 WP_103178550.1 helix-turn-helix transcriptional regulator Antitoxin
N5937_RS06840 (1321429) 1321429..1322817 - 1389 WP_103178549.1 phenylalanine transporter -
N5937_RS06845 (1322921) 1322921..1324894 - 1974 WP_103178548.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13964.90 Da        Isoelectric Point: 7.3567

>T260569 WP_103178551.1 NZ_CP107262:1320735-1321097 [Leclercia adecarboxylata]
MWEVETTDMFDEWFHHQKQDLKEDVLAALHILSEYGPQLGRPWVDTVKASQYTNMKELRIQHAGDPIRAFFAFDPGRQAI
ILCAGNKTGAGDKRFYKRMINIADAEFSKYLASKEAKWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10971.70 Da        Isoelectric Point: 5.1667

>AT260569 WP_103178550.1 NZ_CP107262:1321085-1321384 [Leclercia adecarboxylata]
MATLKELMAQQSEESQERIAAKVEELRIIVALNQLREELNMSQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References