260563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1990360..1990955 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag N5938_RS09280 Protein ID WP_003113526.1
Coordinates 1990360..1990638 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag N5938_RS09285 Protein ID WP_003111575.1
Coordinates 1990650..1990955 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS09260 (N5938_09260) 1985786..1987024 + 1239 Protein_1821 C69 family dipeptidase -
N5938_RS09265 (N5938_09265) 1987086..1987733 + 648 WP_003095021.1 carbonate dehydratase -
N5938_RS09270 (N5938_09270) 1987803..1990031 - 2229 WP_021264080.1 TonB-dependent receptor -
N5938_RS09275 (N5938_09275) 1990179..1990307 + 129 Protein_1824 integrase -
N5938_RS09280 (N5938_09280) 1990360..1990638 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5938_RS09285 (N5938_09285) 1990650..1990955 + 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
N5938_RS09295 (N5938_09295) 1991641..1992372 + 732 WP_263901882.1 STY4528 family pathogenicity island replication protein -
N5938_RS09300 (N5938_09300) 1992394..1992783 + 390 WP_263901883.1 hypothetical protein -
N5938_RS09305 (N5938_09305) 1993384..1994247 + 864 WP_023098850.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T260563 WP_003113526.1 NZ_CP107257:1990360-1990638 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT260563 WP_003111575.1 NZ_CP107257:1990650-1990955 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References