Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1413433..1414088 Replicon chromosome
Accession NZ_CP107247
Organism Coxiella burnetii strain KZQ3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OHM78_RS07665 Protein ID WP_011996617.1
Coordinates 1413750..1414088 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OHM78_RS07660 Protein ID WP_010958263.1
Coordinates 1413433..1413744 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM78_RS07640 (OHM78_07640) 1408725..1409402 - 678 WP_011996613.1 cyclin family protein -
OHM78_RS07645 (OHM78_07645) 1409705..1411087 - 1383 WP_010958260.1 cysteine--tRNA ligase -
OHM78_RS07650 (OHM78_07650) 1411078..1412475 - 1398 WP_005772021.1 glutamate--tRNA ligase -
OHM78_RS07655 (OHM78_07655) 1412632..1413363 + 732 WP_005772022.1 UDP-2,3-diacylglucosamine diphosphatase -
OHM78_RS07660 (OHM78_07660) 1413433..1413744 - 312 WP_010958263.1 HigA family addiction module antitoxin Antitoxin
OHM78_RS07665 (OHM78_07665) 1413750..1414088 - 339 WP_011996617.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM78_RS07670 (OHM78_07670) 1414447..1415592 + 1146 WP_005771875.1 ISAs1-like element ISCbu1 family transposase -
OHM78_RS07675 (OHM78_07675) 1415920..1417593 + 1674 WP_238024397.1 CBU_1493 family Dot/Icm T4SS effector -
OHM78_RS07680 (OHM78_07680) 1417767..1418522 - 756 WP_010958266.1 pyridoxine 5'-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1414447..1415592 1145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-72)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13428.63 Da        Isoelectric Point: 10.2262

>T260560 WP_011996617.1 NZ_CP107247:c1414088-1413750 [Coxiella burnetii]
MPLTLYIMLDVTRKTVILEVMIKSFKDKYTKYLYEGVSVSKWQAIRKQAERRLQILDSVTSLDDLRSLPSNRFESLRGNR
KGQFSIRINKQWRICFKWINNEPTEVEIVDYH

Download         Length: 339 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11458.39 Da        Isoelectric Point: 10.1699

>AT260560 WP_010958263.1 NZ_CP107247:c1413744-1413433 [Coxiella burnetii]
MKMAANRMRPIHPGEILAEELGFLDKMSANQLAKHLAIPTNRVTAILNGARSITADTALRLAKFFGTTPEFWLNLQDAYD
IKMALKKSGKKIEKEVTPYDQAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References