Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2718166..2718761 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA20_RS12855 Protein ID WP_003113526.1
Coordinates 2718166..2718444 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA20_RS12860 Protein ID WP_003133769.1
Coordinates 2718456..2718761 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS12835 (PALA20_02539) 2713591..2714829 + 1239 WP_003095023.1 C69 family dipeptidase -
PALA20_RS12840 (PALA20_02540) 2714891..2715538 + 648 WP_003095021.1 carbonate dehydratase -
PALA20_RS12845 (PALA20_02541) 2715609..2717837 - 2229 WP_023104079.1 TonB-dependent receptor -
PALA20_RS12850 2717985..2718113 + 129 Protein_2538 integrase -
PALA20_RS12855 2718166..2718444 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA20_RS12860 (PALA20_02542) 2718456..2718761 + 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA20_RS12870 (PALA20_02544) 2719433..2720575 + 1143 WP_023098851.1 STY4528 family pathogenicity island replication protein -
PALA20_RS12875 (PALA20_02545) 2721176..2722039 + 864 WP_023098850.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T260500 WP_003113526.1 NZ_CP107064:2718166-2718444 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT260500 WP_003133769.1 NZ_CP107064:2718456-2718761 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References