260453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1544622..1545217 Replicon chromosome
Accession NZ_CP107029
Organism Pseudomonas aeruginosa strain PALA19

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA19_RS07220 Protein ID WP_003113526.1
Coordinates 1544622..1544900 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA19_RS07225 Protein ID WP_003113527.1
Coordinates 1544912..1545217 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA19_RS07200 (PALA19_01428) 1540048..1541286 + 1239 WP_003113524.1 dipeptidase -
PALA19_RS07205 (PALA19_01429) 1541348..1541995 + 648 WP_003095021.1 carbonate dehydratase -
PALA19_RS07210 (PALA19_01430) 1542065..1544293 - 2229 WP_023086667.1 TonB-dependent receptor -
PALA19_RS07215 1544441..1544569 + 129 Protein_1422 integrase -
PALA19_RS07220 1544622..1544900 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA19_RS07225 (PALA19_01431) 1544912..1545217 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA19_RS07235 (PALA19_01433) 1545624..1546724 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA19_RS07240 (PALA19_01434) 1546765..1547349 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA19_RS07245 (PALA19_01435) 1547391..1548005 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA19_RS07250 1548122..1549063 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA19_RS07260 (PALA19_01437) 1549230..1550078 - 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T260453 WP_003113526.1 NZ_CP107029:1544622-1544900 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT260453 WP_003113527.1 NZ_CP107029:1544912-1545217 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References